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Sandiso Ngwenya’s academic journey began with a question: how can Africa ensure that pharmaceuticals are available for its people? As a naturally curious person with an unwavering drive to make an impact, this question became the driving force behind her career. “I became fascinated with pharmaceutical drug manufacturing, and specifically with the processes and costs involved,” she says.
In 2014, Ngwenya moved to South Africa, where she began a BSc in Chemistry and Chemicals. A year later, she joined Nelson Mandela University, where she earned a BSc Hons in Formulation Science and later a Master of Science (Chemistry). Today, she is pursuing a PhD in pharmaceutical chemistry.
Nelson Mandela University’s Faculty of Science was key in shaping Ngwenya’s path. With its transdisciplinary approach and commitment to addressing societal challenges, the faculty equips ambitious researchers, such as Ngwenya, with the critical thinking and problem-solving skills to excel in a rapidly evolving global economy.
From school labs to nationwide impact
At the heart of the faculty’s mission is a passion for both teaching and advanced research. Here, you’ll find a mix of programmes, including postgraduate degrees in Biochemistry and Chemistry, and research opportunities that challenge you to think critically and spark an interest in discovery that will stay with you throughout your life.
You will be mentored by industry leaders, including South African Research Chairs and National Research Foundation-rated scientists. Among them is Professor Paul Watts, who leads a research group focused on using flow chemistry to produce drug ingredients locally, potentially making essential medicines more affordable.
Students are equally encouraged to engage in impactful research. Ngwenya’s research focuses on synthesising a library of Coumarin compounds. These compounds play a vital role as building blocks in producing Active Pharmaceutical Ingredients (APIs).
“We use continuous flow chemistry (or micro-reaction technology), a new and emerging technology in the African market, to find a cost-effective, high-yielding method for synthesising Coumarins,” she says. “Continuous flow chemistry employs miniature reactors that enable uninterrupted chemical reactions within controlled systems. This method offers numerous advantages, such as shorter reaction times, better product selectivity, fewer by-products, and increased yields for reactions, among many others.”
Her research has the potential to facilitate on-demand local production of APIs, reducing reliance on expensive imports from first-world countries and lowering healthcare costs for South Africans.
The department provides access to state-of-the-art facilities to support students and staff in their research. One example is InnoVenton, a research institute that incorporates the Downstream Chemicals Technology Station. This government-funded initiative provides high-level research, technological services, and training to technology-based small and medium enterprises, as well as the South African industry.
In 2024, 15,687 science students graduated with the knowledge and intra- and inter-personal skills needed for success. Source: Nelson Mandela University
Real-world solutions for real-world challenges
Outside the classroom, science students have plenty of opportunities to gain practical experience. The goal is to help you become engaged and transdisciplinary scientists who can tackle real-world social, economic, and environmental issues. In 2024, eight students honed their entrepreneurial skills at a Dragon’s Den-type event at InnoVenton, where they developed business plans and pitched their ideas to potential investors.
“These students are working on solutions to societal challenges and they come up with their ideas on their own. We allow them to be creative,” says senior lecturer and course coordinator Dr. Nicole Vorster. While some projects require further development, many demonstrated clear “proof of concept,” demonstrating the resourcefulness of students.
Pharmacy graduate Joshua Kruger, for instance, developed a water filter using hydrogel beads made from seaweed and crustacean shells — an eco-friendly solution to water purification. Meanwhile, Lebogang Matinketsa created a garlic extract-infused toothpaste that effectively reduces plaque build-up and combats bad breath.
The University has a support system for researchers in place as well. The Office of Research Development provides statistical training and consultations via the Unit for Statistical Consultation, manages human and animal ethics, and facilitates professional growth through year-long face-to-face or virtual workshops.
Student well-being is another priority for the faculty. “Imposter syndrome has always been a huge factor during my research,” says Ngwenya. “I was fortunate enough to have access to student counselling, which helped me navigate the challenges I faced during my academic journey.”
The Faculty of Science has shaped many successful alumni who are now making a real impact in their fields, like Dr. Dale Peterson. His work in digestive health is transforming lives at Melomed Tokai Hospital, proof of the far-reaching impact of the faculty’s dedication to excellence in education and research.
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